CBD Oil for Kidney Disease:
CBD may provide support for kidney disease through its anti-inflammatory, antioxidant, and analgesic benefits.
But there are some limitations to be aware of.
Can CBD help with kidney disease, and if so, how?
Kidney failure, also called renal failure or end-stage renal disease, is the last stage of chronic kidney disease.
When the kidneys fail, it means they have stopped working well enough for the person to survive without dialysis or a kidney transplant(
However, even these remedies are not without adverse side effects. For instance, researchers found an increased incidence of kidney stones in patients after a kidney transplant.
Calcium based stones, such as calcium oxalate and calcium phosphate, were the most common types of kidney stones found after kidney transplantation
Meanwhile, studies have examined the use of nonsteroidal anti-inflammatory drugs (NSAIDs) for chronic kidney disease (CKD).
Findings suggested that short-term NSAID use has adverse side effects on blood pressure elevation
High blood pressure is the second principal cause of kidney failure in the United States after diabetes
CBD for Kidney Disease: What the Research Says
There are no studies specific to the use of CBD alone and its impact on kidney health. There are, however, limited studies that examined the effects of cannabis on kidneys, and they produced mixed results.
During the American Society of Nephrology’s Kidney Week conference in October 2018, researchers shared their findings from a recent study on medical marijuana use and its side effects on kidneys.
Marijuana and hemp belong to the same plant species, Cannabis sativa, but are widely different. Marijuana contains much more tetrahydrocannabinol (THC) than hemp, while hemp contains more cannabidiol (CBD).
The researchers, who studied kidney disease progression in cannabis users, found that chronic kidney disease (CKD) patients’ kidney function declined faster in those who used cannabis, compared to those who did not. They did not report whether this was marijuana or hemp-derived cannabis which would have lower THC than CBD.
Joshua L. Rein, DO, who led the study, warned that kidney patients using cannabis should be aware of potential symptoms, such as nausea, lack of appetite, and chronic pain, which are all valid issues for medical marijuana usage.
Meanwhile, researchers of a study published in the Journal of Pain and Symptom Management believe that even minor improvements in patients with difficult-to-treat CKD symptoms may be clinically meaningful
In their research, they found that cannabinoids, like CBD and THC, may present a reasonable alternative to pain and symptom management.
Another study, which was published in the Journal of Pharmacology and Experimental Therapeutics, showed that CBD might help reduce nephrotoxicity by decreasing oxidative stress, inflammation, and cell death
Nephrotoxicity occurs when the body is exposed to a drug or toxin that causes kidney damage, which makes the body unable to eliminate excess urine and wastes.
Still, due to limited treatment options for chronic kidney disease (CKD), symptom management can be challenging.
Thus, therapeutic alternatives are in high demand, which may explain why, in recent years, medical marijuana has emerged as an attractive therapeutic option
As a result, medical cannabis continues to be used for a variety of indications with minimal guidance on known risks, particularly on the altered physiological state of patients with chronic kidney disease (CKD)
How CBD Works: The Endocannabinoid System Explained
According to a study published in the American Journal of Physiology – Renal Physiology in 2017, the endocannabinoid system (ECS) plays a crucial role in renal homeostasis.
While data suggest cannabis and cannabinoids could have essential effects on kidney function, there is not sufficient evidence from clinical research studies to determine the dangers faced by users of these products with respect to the development of acute kidney injury (AKI) or CKD
A 2016 review looked into the emerging role of the endocannabinoid system, particularly the cannabinoids and the cannabinoid receptors, in normal kidney function and other diseases, such as diabetes and obesity, that directly contribute to the development of renal diseases
The authors of the said review found that the activation of the CB1 receptor regulates renal vascular blood flow. Meanwhile, the renal CB2 receptor reduces the effects of inflammation, oxidative stress, and renal fibrosis.
Here’s how you can get started using CBD oil today.